Extracellular antibodies are ideal research tools for cell-surface proteins.

No permeabilization/fixation because using extracellular antibodies allows you to work with live cells!

Benefits of live cell imaging:
✓ Monitor cell movement
✓ Study protein transport across the cell
✓ Investigate protein internalization

K⁺ channels are tetrameric integral membrane proteins that form aqueous pores through which K⁺ can flow, and are found in many organisms. In neurons, K⁺ channels are involved in maintaining the resting potential, repolarizing the membrane after action potentials, and controlling the timing of repetitive firing.