Extracellular antibodies are ideal research tools for cell-surface proteins.

No permeabilization/fixation because using extracellular antibodies allows you to work with live cells!

Benefits of live cell imaging:
✓ Monitor cell movement
✓ Study protein transport across the cell
✓ Investigate protein internalization

K_V1.3 channels are widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. K_V1.3 expression/function in T-lymphocytes is responsible for maintaining the resting potential in quiescent cells and regulating Ca²⁺ signaling, a function which is indispensable for normal T-lymphocyte activation.