Overview
Cat #:
A-205
Lyophilized Powder yes
Source Synthetic
MW: 395.41
Purity: >98%
Effective concentration 1-100 µM.
Structure
Chemical name 3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate.
Molecular formula C20H21N5O4.
CAS No.: 149685-89-2
Activity 3-AQC is a potent and selective 5-HT3A receptor antagonist1.
References-Activity
- Monge, A. et al. (1993) J. Med. Chem. 36, 2745.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs 3-AQC blocks 5-HT3A channels expressed in HEK 293T cells.Currents were elicited by 10 µM 5-HT, delivered every 3 minutes. 3-AQC (#A-205) was applied 30 seconds before stimulation at 10 and 100 µM, as indicated, and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
Scientific background
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.
3-AQC is a potent and selective antagonist of the 5-HT3A channel. 3-AQC is a derivative of Piperazinyquinoxaline synthetically designed to be 100 times more potent in blocking Serotonin receptors than Tropisetron.
Target 5-HT3A channel
Lyophilized Powder
For research purposes only, not for human use
Last Update: 03/01/2024
Specifications
Citations
Citations
