Overview
- Newman, A.S. et al. (2013) Br. J. Pharmacol. 169, 1228.
Alomone Labs 5-Chloroindole potentiates the response to 5-HT of 5-HT3A receptors expressed in HEK 293T cells.5-HT3A receptor currents were elicited by 1 µM 5-HT, delivered every 3 minutes. 5-Chloroindole (#C-260) was applied 30 seconds before stimulation at 1, 10 and 100 µM, as indicated, and enhanced the 5-HT induced current in a dose-dependent and reversible manner.
5-Chloroindole is a potent and selective allosteric modulator of the 5-HT3 receptor that displays micromolar potency.
The 5-HT3 receptor belongs to the Cys-loop ligand-gated ion channel superfamily. It mediates fast synaptic neurotransmission in neurons of both the central and peripheral nervous systems.
5-Chloroindole can assist in the investigation of the molecular basis for allosteric modulation of the 5-HT3 receptor and may contribute to the discovery of novel therapeutic drugs targeting the 5-HT3 receptor1. 5-Chloroindole is also used as a strong inhibitor of the copper dissolution in acidic sodium chloride solution2. Several different studies have shown that 5-chloroindole has the ability to decrease serotonin levels in the brainstem and in the telencephalon3.
