Overview
Cat #: AK-105
Size: 12 Vials
Form: Lyophilized
Alomone Labs is pleased to offer the Adenosine Receptor Antibody Explorer Kit (#AK-105). This Explorer Kit includes antibodies targeting Adenosine receptors along with their respective control peptide antigen. An ideal tool for screening purposes.
For research purposes only, not for human use
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-Adenosine A1 Receptor Antibody |
AAR-006 | 1 x 50 µl |
Adenosine A1 Receptor Blocking Peptide |
BLP-AR006 | 1 x 40 µg |
Anti-Adenosine A2A Receptor Antibody |
AAR-002 | 1 x 50 µl |
Adenosine A2A Receptor Blocking Peptide |
BLP-AR002 | 1 x 40 µg |
Anti-Adenosine A2A Receptor (extracellular) Antibody |
AAR-008 | 1 x 50 µl |
Adenosine A2A Receptor (extracellular) Blocking Peptide |
BLP-AR008 | 1 x 40 µg |
Anti-Human Adenosine A2A Receptor (extracellular) Antibody |
AAR-007 | 1 x 50 µl |
Human Adenosine A2A Receptor (extracellular) Blocking Peptide |
BLP-AR007 | 1 x 40 µg |
Anti-Adenosine A2B Receptor (extracellular) Antibody |
AAR-003 | 1 x 50 µl |
Adenosine A2B Receptor (extracellular) Blocking Peptide |
BLP-AR003 | 1 x 40 µg |
Anti-Adenosine A3 Receptor Antibody |
AAR-004 | 1 x 50 µl |
Adenosine A3 Receptor Blocking Peptide |
BLP-AR004 | 1 x 40 µg |
Scientific Background
Scientific Background Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart1,2. It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1-Adenosine Receptor (A1AR), A2A-Adenosine Receptor (A2AAR), A2B-Adenosine Receptor (A2BAR), and A3-Adenosine Receptor (A3AR). All are integral membrane proteins and members of the G-protein coupled receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important in binding G proteins1-3. The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs1-3.
References
- Okusa, M.D. (2002) Am. J. Physiol. 282, F10.
- Nakata, H. (1989) J. Biol. Chem. 264, 16545.
- Linden, J. (1991) FASEB J. 5, 2668.
