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Home › Products › Ion Channels › Ca2+ Signaling › Voltage-Gated Ca2+ Channels › Blockers

Certificate of Analysis

CaV2 Channel Blocker Explorer Kit

A Screening Package of CaV2 Channel Blockers Economically Priced

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Cat #: EK-110
Size: 21 Vials
Form: Lyophilized

α-Conotoxin PeIA Cat #: STC-970

Size: 0.1 mg MW: 1652 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
20-50 nM.
Activity
α-Conotoxin PeIA blocks α9/α10 and α3/β2 nAChR1. Also inhibits N-type Ca2+ channels2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two week at 4°C or three months at -20°C.

ω-Agatoxin IVA Cat #: STA-500

Size: 0.1 mg MW: 5202 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
20 nM - 1 µM.
Activity
ω-Agatoxin IVA is an antagonist of voltage-sensitive P-type Ca2+ channels1. It blocks neuromuscular transmission presynaptically in a variety of synapses2,3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Agatoxin TK Cat #: STA-530

Size: 50 µg MW: 5273 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
20 nM - 1 µM.
Activity
ω-Agatoxin TK is an antagonist of voltage-sensitive P-type Ca2+ channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water, or 0.9% NaCl solution. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.

ω-Conotoxin CnVIIA Cat #: STC-800

Size: 0.1 mg MW: 2848 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-5 µM.
Activity
ω-Conotoxin CNVIIA inhibits N-type Ca2+ channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin CVIA Cat #: STC-750

Size: 50 µg MW: 2642 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
50-200 nM.
Activity
ω-Conotoxin CVIA is an N-type Ca2+ channel blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin CVIB Cat #: STC-410

Size: 50 µg MW: 2710 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-10 nM.
Activity
ω-Conotoxin CVIB is a N-, P- and Q-type calcium channel blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin CVIC Cat #: STC-420

Size: 50 µg MW: 2783 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-50 nM.
Activity
ω-Conotoxin CVIC is a blocker of N-, P/Q-type CaV channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin CVIE Cat #: STC-760

Size: 50 µg MW: 2640 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-10 nM.
Activity
ω-Conotoxin CVIE is a selective voltage-gated N-type Ca2+ channel inhibitor1-3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin GVIA Cat #: C-300

Size: 0.1 mg MW: 3037 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
20 nM - 1 μM.
Activity
ω-Conotoxin GVIA specifically and reversibly blocks N-type CaV channels1 and is reported to antagonize P2X receptors2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin MVIIA Cat #: C-670

Size: 0.1 mg MW: 2639.2 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
100 nM - 2 µM.
Activity
ω-Conotoxin MVIIA specifically blocks N-type CaV channels1 and also inhibits K+-induced 3H-GABA release in the hippocampus in vivo2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or six months at -20°C.

ω-Conotoxin MVIIC Cat #: C-150

Size: 0.1 mg MW: 2750 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
50 nM - 1 μM.
Activity
ω-Conotoxin MVIIC blocks P/Q- and N-type CaV channels1. ω-Conotoxin MVIIC is also reported to block nicotinic receptors heterologously expressed in Xenopus oocytes with an IC50 of 1.3 μM2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin MVIID Cat #: STC-751

Size: 50 µg MW: 2695 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
200 nM - 1 µM.
Activity
ω-Conotoxin MVIID is a voltage-gated N-type Ca2+ channel blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin RVIA Cat #: STC-850

Size: 0.1 mg MW: 2915 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-5 µM.
Activity
CaV2.2 channel blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

ω-Conotoxin SO3 Cat #: STC-470

Size: 0.1 mg MW: 2561 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
20-500 nM.
Activity
ω-Conotoxin SO3 is a selective N-type Ca2+ channel inhibitor1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Cilnidipine Cat #: C-135

Size: 5 mg Source: Synthetic MW: 492.5 Purity: >98.5%
Effective concentration
1-100 µM.
Activity
Cilnidipine is an L- and N-type Ca2+-channel blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

FTX-3.3 Cat #: F-120

Size: 1 mg Source: Synthetic MW: 273.4 Purity: >99%
Origin
Agelenopsis aperta (North American funnel-web spider).
Effective concentration
0.1-1 mM.
Activity
FTX-3.3 is a synthetic polyamine1-2, reputed to be structurally identical to the native Funnel Web Spider Toxin (FTX). It blocks P-, N-, and L-type Ca2+ channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

sFTX-3.3 Cat #: F-130

Size: 1 mg Source: Synthetic MW: 287.4 Purity: >95%
Effective concentration
0.1-1 mM.
Activity
sFTX-3.3, a synthetic funnel web spider toxin1-2, is a polyamine amide analogue of FTX. It blocks P-, N-, and L-type Ca2+ channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Huwentoxin-I Cat #: STH-050

Size: 0.1 mg Source: Synthetic peptide MW: 3750 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Chinese bird spider (Haplopelma schmidti, Ornithoctonus huwena)
Effective concentration
50-200 nM
Activity
An inhibitor of TTX-sensitive voltage-gated Na+ channels and N-type voltage-gated Ca2+ channels1. Also found to block neuromuscular transmission2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

PD 173212 Cat #: P-105

Size: 5 mg Source: Synthetic MW: 599.9 Purity: >99%
Effective concentration
10 nM - 10 μM.
Activity
PD 173212 is a dipeptidyl-amine that acts as an N-type voltage-gated Ca2+ channel blocker1. PD 173212 inhibited N-type channels in IMR-32 cells with IC50 = 36 nM as measured by Ca2+ imaging of K+ stimulated cells and only had small effects on other channels at much higher concentrations1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SNX-482 Cat #: RTS-500

Size: 50 µg MW: 4495 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Recombinant, E. coli
Effective concentration
10-100 nM.
Activity
SNX-482 blocks R-type (CaV2.3) and P/Q-type (CaV2.1) voltage-gated Ca2+ channels1. It also blocks A-type K+ channels with an IC50 < 3 nM2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
For more information, please refer to individual certificate of analysis for each product.
For research purposes only, not for human use

Related Products

  1. Anti-CACNA1A (CaV2.1) Antibody (#ACC-001)
  2. Anti-CACNA1B (CaV2.2) Antibody (#ACC-002)
  3. Anti-CaV2.3 (CACNA1E) Antibody (#ACC-006)
  4. L-Type CaV Channel Antibody Explorer Kit (#AK-215)
  5. Non-L-Type CaV Channel Antibody Explorer Kit (#AK-216)
  6. L-Type CaV Channel Blocker Explorer Kit (#EK-103)
  7. T-Type CaV Channel Blocker Explorer Kit (#EK-111)

Resources

  • N-Type (CaV2.2) Channels
  • P/Q-Type (CaV2.1) Channels

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We offer 100% guarantee on all our products. If our products do not perform as stated, please contact our technical support staff.

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Resources

  • N-Type (CaV2.2) Channels

  • P/Q-Type (CaV2.1) Channels

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