1-500 µM.

α-Asarone 100 μM to 1 mM inhibits Na_V1.2 channel currents. It also blocks GABA(A) receptors in neurons¹. α-Asarone blocks corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Bungarus multicinctus (Many-banded krait).

1 nM - 3 μM.

α-Bungarotoxin blocks postsynaptic neuromuscular transmission via competitive inhibition of nicotinic ACh receptors (nAChRs), thereby preventing the depolarizing action on postsynaptic membranes and blocking neuromuscular transmission. Selective for α7 receptors (IC₅₀ value of 1.6 nM) and α3/β4 receptors (IC₅₀ value of >3 μM)^1,2. The toxin also blocks GABA(A) receptor subtypes³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

0.5 nM – 0.5 µM.

Amentoflavone is a negative allosteric modulator of GABA(A) receptor inhibitory activity, with EC₅₀=4 µM on recombinant α1β2γ2L GABA(A) in oocytes¹. In vitro, it potently displaces benzodiazepine binding to rat brain membranes with nM affinity², and inhibits binding at other GPCRs³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-100 µM.

(+)-Bicuculline inhibits (IC₅₀ = 9 µM) recombinant α1β1γ2 GABA(A) channels that were activated with 3 µM GABA¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO (with gentle warming), DMF, chloroform. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-100 µM.

Bilobalide is a 5-HT3A¹ and GABAA² channel blocker.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-1 µM.

Gabazine is a competitive antagonist of the GABA(A) receptor, selectively inhibiting GABA-evoked currents (IC₅₀ = 0.44 µM), but not currents evoked by pentobarbiton and etomidate¹. It is also a low-affinity glycine receptor antagonist (K_B = 191 µM)².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Soluble in water, DMSO and methanol. Centrifuge all product preparations before use (10000 x g, 5 min).

Up to three months at -20°C.

0.01-10 μM.

Ganaxolone potentiates GABA-evoked chloride currents. In Xenopus oocytes expressing the human GABA(A) receptor subunits α2β1γ2L, α3β1γ2L and α1β1γ2L the respective EC₅₀ values are 94, 122 and 213 nM¹. It is also used as an anticonvulsant, antiepileptic drug².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-100 µM.

Picrotoxin, an equimolar mixture of picrotoxinin and picrotin, is a non-competitive antagonist of the GABA(A) receptors (IC₅₀ = 2.4 µM – 17 µM)¹, an antagonist of glycine receptors (IC₅₀ = 2.7 µM – 6.4 µM)² and of 5-HT3 receptors (IC₅₀ = 41.2 µM)³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.

Soluble in DMSO and ethanol. Centrifuge before use (10000 x g, 5 min).

Up to three months at -20°C.

1-100 µM.

SJM-3 is a novel positive allosteric modulator of GABA(A) receptors at the benzodiazepine modulatory site (pK_i = 6.7), strongly potentiating GABA currents at 30 µM via the binding site for diazepam in the transmembrane domain, while acting as an antagonist at the α+/γ− site¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Soluble in DMSO. Centrifuge before handling (10000 x g, 5 min).

-20°C.

10-100 µM.

Tracazolate is an allosteric modulator of GABA(A) receptors, that was shown to potentiate (EC₅₀ = 1.1-16.7 µM) or inhibit (IC₅₀ = 1.2-4.0 µM) GABA-evoked currents in a subunit combination dependent manner¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C. Protect from light.

Soluble in 1eq. HCl and in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

1- 5 µM.

Waglerin-1 blocks ε subunit of muscle adult nAChR and modulates rodent GABA(A)/GABRA1 receptors^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.