1-100 μM.

CyPPA is an activator of small conductance Ca²⁺-activated K⁺ channels K_Ca2.2 (SK2) and K_Ca2.3 (SK3) with EC₅₀ values of 5.6 and 14 μM for SK3 and SK2 respectively. It displays no activity at SK1 and intermediate conductance K_Ca (IK) channels¹. CyPPA blocks TRPM7 channels².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

5-100 μM.

1-EBIO is an activator of K_Ca3.1 and K_Ca2 channel currents¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

250 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural product of unspecified plant origin.

1-100 μM.

Isopimaric acid is a potent opener of large conductance Ca²⁺-activated K⁺ (BK) channels. 1 μM of Isopimaric acid doubles the current carried via BK channels. Isopimaric acid may increase the open probability by shifting the Ca²⁺ and voltage dependence to more hyperpolarized voltages¹. The sensitivity is decreased in the Xenopus system compared to mammalian cells. BK channels activated by Isopimaric acid retain their charybdotoxin sensitivity.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO, ethanol, acetone or methanol. DMSO is suggested for biological experiments. DMSO solution should not exceed 0.03%. Centrifuge all product preparations before use (10000 x g 5 min).

Up to three months at -20°C.

0.5-50 µM.

NS-11021 is a potent K_Ca1.1 channel agonist, enhancing K_Ca1.1 currents with EC₅₀ of 0.4 µM, whilst having no effect on a variety of K⁺, Na⁺ and Ca²⁺ channels at 10 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

100 nM - 100 μM.

NS-1619 is a potent and selective K_Ca1.1 (BK, slo, Large conductance Ca²⁺-activated K⁺) channel modulator (enhancer)¹. NS-1619 was effective in eliciting and enhancing K_Ca1.1 channels in smooth muscle as well as in neurons with maximal effects at concentrations around 30 μM^1,2. NS-1619 was used in vivo by intracarotid infusion and significantly enhanced blood tumor barrier permeability in the brain tumor area but not in normal brain tissue³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

5 µM – 100 µM.

NS19504 is a K_Ca1.1 channel opener¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1 - 10 µM.

NS-309 is a positive modulator of small- and intermediate- conductance Ca²⁺-activated K⁺ (K_Ca2 and K_Ca3.1) channels, with EC₅₀ values of 30 and 10 nM, respectively¹. NS-309 also blocks L-type Ca²⁺ channels with IC₅₀ value of 10 μM².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural product of unspecified plant origin.

1-10 µM.

Pimaric acid is a potent opener of large conductance Ca²⁺-activated K⁺ (BK) channels. 1 µM of Pimaric acid doubles the current carried via BK channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Organic solvents such as DMSO, ethanol, acetone or methanol. DMSO is suggested for biological experiments. DMSO solution should not exceed 0.03%. Centrifuge all product preparations before use (10000 x g 5 min).

Up to three months at -20°C.

0.1-10 µM.

SKA-31 is an activator of K_Ca3.1 and K_Ca2 channels (EC₅₀ values are 260, 2900, 2900 nM for K_Ca3.1, K_Ca2.1 and K_Ca2.2 respectively)¹. Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice^1,2. SKA-31 blocks TRPM7³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

100 nM - 10 µM

SKA-121 is a positive gating modulator of K_Ca3.1 channels (EC₅₀ of 109 nM), potent and selective over K_Ca2 subtypes (EC₅₀ of 4.4-8.7 μM). Significantly lowers mean arterial blood pressure in vivo in wild-type hypertensive mice (100 mg/kg i.p.)¹.

Store at -20°C.

Soluble in DMSO. Spin down all products before handling.

Store at -20°C. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

10-200 µM.

Tanshinone II-A sodium sulfonate  is a K_Ca1.1 channel opener¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

10 mM in H₂O. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.