Synthetic peptide

1-5 µM.

AamTx3 Toxin is a blocker of A-type voltage-gated K⁺ channels as well as ERG1, K_V11.1 and KCNH2 K⁺ channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

1-100 nM.

Guangxitoxin-1E is a gating modifier of K_V2.1 (KCNB1, IC₅₀ of 1 nM), K_V2.2 (KCNB2, IC₅₀ of 3 nM) and K_V4.3 (KCND3, IC₅₀ of 10-20 fold higher concentration) channels. In pancreatic β cells it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations^1,2. The physiological modulation of K_V2.1 channels during glucose-induced insulin secretion is MgATP-mediated³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100-500 nM.

Heteropodatoxin-2 is an inhibitor of voltage-gated K⁺ channels of the K_V4 family. Inhibition of K_V4.3 and K_V4.2 is strongly voltage-dependent, while inhibition of K_V4.1 shows less voltage-dependence. Lacks affinity for K_V1.4, K_V2.1 and K_V3.4^1,2. Also blocks Ca²⁺ channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

5-10 nM.

Jingzhaotoxin-V inhibits TTX-resistant and TTX-sensitive Na⁺ channels in DRG neurons. It also highly inhibits K_V4.2 and K_V4.3 K⁺ channels and weakly inhibits K_V2.1 K⁺ channels. It has no effect on K_V1.2, K_V1.3 or K_V1.4 K⁺ channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

200 nM - 2 µM.

Jingzhaotoxin-XII inhibits K_V4.1 and Na_V1.5 voltage-gated channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-200 nM.

Pandinotoxin Kα is an A-type and Shaker-related K⁺ channel blocker^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

Phrixotoxin-1 specifically and reversibly blocks K_V4.2 and K_V4.3 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100-500 nM

Phrixotoxin-2 specifically and reversibly blocks K_V4.2¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Recombinant, E. coli

10-100 nM.

SNX-482 blocks R-type (Ca_V2.3) and P/Q-type (Ca_V2.1) voltage-gated Ca²⁺ channels¹. It also blocks A-type K⁺ channels with an IC₅₀ < 3 nM².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.