Recombinant, E. coli

ED₅₀ = 220 pM.

BDNF is a neurotrophic factor and binds p75^NTR as well as TrkB receptors^1,2. BDNF supports the survival of many cell types^3-8.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = 1 nM.

CNTF is a potent neurotrophic factor that was originally characterized as a survival factor for chick ciliary neurons. CNTF supports growth and survival of DRG, motor and sympathetic neurons^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 μg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = 20 pg/ml.

EGF is a potent growth factor that stimulates both in vitro and in vivo the proliferation of various epidermal and epithelial cells¹. Fibroblasts are also stimulated in vitro by EGF^2,3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 μg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = ~17 pM.

FGF-basic is a heparin binding growth factor which stimulates the proliferation of a wide variety of cells, including mesenchymal, neuroectodermal, endothelial, and smooth muscle cells, among many others. FGF-basic also induces neuronal and glial differentiation, survival and regeneration^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

GDNF enhances survival and differentiation of dopaminergic neurons. It is also a potent survival factor for motor neurons^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = ~10 pM.

LIF is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF regulates cholinergic, peptidergic and noradrenergic properties of sympathetic neurons and rescues sensory and motor neurons from death. LIF also promotes differentiation of O-2A astrocytes^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

The ED₅₀ as determined by a cell proliferation assay using FDC-P1 cells is less than 2.0 ng/ml, corresponding to a specific activity of >500,000 units/mg.
rat IGF-I is fully biologically active when compared to standards. The ED₅₀ shown in literature was calculated in two different methods: 1. Stimulation of protein synthesis in rat L6 myoblasts ED₅₀ was found to be less than 30 ng/ml. 2. Type 1 IGF receptor binding assay ED₅₀ was found to be less than 10 ng/ml.

IGF-I is a pleiotropic factor involved in multiple processes, so its actions are different depending on its concentration, the cell type, and the developmental stage of the animal¹. IGF-I promotes proliferation of neural cells by interacting with the IGF-IR which may activate the PI3K/Akt or the MAP kinase pathways¹.
Evidence indicates that IGF-I promotes cell survival by inhibiting apoptosis both in vivo and in vitro. IGF-I is also involved in the regulation of the migration of certain cell types¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.