Synthetic peptide

1-5 µM.

AamTx3 Toxin is a blocker of A-type voltage-gated K⁺ channels as well as ERG1, K_V11.1 and KCNH2 K⁺ channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100 nM - 5 µM.

BDS-I inhibits 60% of K_V3.4 current. The blocking effect is rapid, direct and reversible¹. BDS-I also modulates voltage-gated Na⁺ channels. It enhances TTX-sensitive Na⁺ channels (highly effective on Na_V1.7 channels), and weakly inhibits TTX-resistant Na_V channels².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Anemonia sulcata (Mediterranean snakelocks sea anemone).

100 nM - 5 µM.

BDS-II blocks the K_V3.4 current. The blocking effect is rapid, direct and reversible¹. BDS-II also modulates voltage-gated Na⁺ channels (in-house data).

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

1-100 nM.

Guangxitoxin-1E is a gating modifier of K_V2.1 (KCNB1, IC₅₀ of 1 nM), K_V2.2 (KCNB2, IC₅₀ of 3 nM) and K_V4.3 (KCND3, IC₅₀ of 10-20 fold higher concentration) channels. In pancreatic β cells it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations^1,2. The physiological modulation of K_V2.1 channels during glucose-induced insulin secretion is MgATP-mediated³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100-500 nM.

Heteropodatoxin-2 is an inhibitor of voltage-gated K⁺ channels of the K_V4 family. Inhibition of K_V4.3 and K_V4.2 is strongly voltage-dependent, while inhibition of K_V4.1 shows less voltage-dependence. Lacks affinity for K_V1.4, K_V2.1 and K_V3.4^1,2. Also blocks Ca²⁺ channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

200-500 nM.

Inhibits Na_V1.5 and K_V2.1 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

5-10 nM.

Jingzhaotoxin-V inhibits TTX-resistant and TTX-sensitive Na⁺ channels in DRG neurons. It also highly inhibits K_V4.2 and K_V4.3 K⁺ channels and weakly inhibits K_V2.1 K⁺ channels. It has no effect on K_V1.2, K_V1.3 or K_V1.4 K⁺ channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

0.5-1 µM.

Jingzhaotoxin-IX blocks Na_V1.4, Na_V1.5 and K_V2.1 voltage-gated channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

200 nM - 2 µM.

Jingzhaotoxin-XII inhibits K_V4.1 and Na_V1.5 voltage-gated channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

Phrixotoxin-1 specifically and reversibly blocks K_V4.2 and K_V4.3 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

100-500 nM

Phrixotoxin-2 specifically and reversibly blocks K_V4.2¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10,000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

ProTx-I inhibits voltage-gated Ca²⁺ (Ca_V3.1), K⁺ (K_V2.1), and all Na⁺ channels tested (Na_V1.2, Na_V1.5, Na_V1.7 and Na_V1.8). The toxin shifts the voltage-dependence of channel activation to more positive potentials.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

0.1-10 µM.

RY796 is a blocker of K_V2.2 and K_V2.1 channels, with IC₅₀ of 0.09 and 0.25 µM respectively¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

Recombinant, E. coli

10-100 nM.

SNX-482 blocks R-type (Ca_V2.3) and P/Q-type (Ca_V2.1) voltage-gated Ca²⁺ channels¹. It also blocks A-type K⁺ channels with an IC₅₀ < 3 nM².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

1.2-670 nM

Stromatoxin-1 is a potent inhibitor of voltage-gated K⁺ channels. It inhibits delayed K_V2.1, K_V2.1/9.3, K_V2.2, and transient K_V4.2 channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all products preparations before use (1000 X g 5 min).

Up to one week at 4°C or three months at -20°C.