Overview
Cat #:
T-220
Alternative Name DBHQ
Lyophilized Powder yes
Source Synthetic
MW: 222.33
Purity: >97%
Effective concentration 1-10 μM.
Structure
Chemical name 2,5-Ditert-butylbenzene-1,4-diol.
Molecular formula C14H22O2.
CAS No.: 88-58-4
Activity tBuBHQ is an inhibitor of the endoplasmic reticulum Ca2+-ATPase1.
References-Activity
- Kass, G. E.N. et al. (1989) J. Biol. Chem. 264, 15192.
Shipping and storage Up to two years at room temperature.
Solubility Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C.
Protect from light.
Protect from light.
Scientific background tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcoplasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose-dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store-operated Ca2+ depletion1. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion2.
Target SERCA
Lyophilized Powder
For research purposes only, not for human use
Last Update: 02/01/2024
Specifications
Citations
Citations
