0.5 nM - 50 µM.

AM 404 activates TRPV1 channels with EC₅₀ = 0.04 µM¹, and serves as a ligand for CB1 cannabinoid receptors².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO, 50 mM in ethanol (dissolves slowly). Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1 nM – 1 µM.

Arvanil is an agonist of TRPV1 channels (EC₅₀ = 0.5 nM), a ligand of CB1 receptors (K_i = 0.25-0.5 μM), and an inhibitor of anandamide accumulation (IC₅₀ = 3.6 µM). In vivo it demonstrates vasodilator, analgesic, and anti-inflammatory properties. Arvanil inhibits human breast cancer cell proliferation and the growth of astrocytoma xenograft tumors in mice^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C.

Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-10 μM.

Capsaicin is one of the most powerful chemical agonists of the TRPV1 (transient receptor potential vanilloid) channel. It is a small lipophilic molecule derived from hot chili peppers that acts on sensory neurons by opening TRPV1, a principal transduction channel for nociception¹. Capsaicin acts directly on TRPV1², with half-maximal effective concentration of 711.9 nM in Xenopus oocytes³ and 0.29 μM in HEK293 cells⁴.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

1-100 µM.

Capsiate activates TRPV1 and TRPA1 channels with EC₅₀ = 3 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

100 nM - 10 µM.

Nonivamide is a TRPV1 activator¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.5 nM – 50 µM.

OLDA activates TRPV1 channels with an EC₅₀ ~ 0.36 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Ethanol and DMSO up to 50 mM. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.5 nM - 50 µM.

Olvanil is an opener of TRPV1 channels (EC₅₀ ~ 0.001 µM)¹ and an activator of Cannabinoid receptors².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Ethanol (up to 20.9 mg/ml). Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

5 nM - 5 µM.

Palvanil activates TRPV1 channels at 100 nM in a slower manner than capsaicin¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO 10 mM. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.