10 nM - 1 µM.

A 784168 is a potent TRPV1 antagonist, inhibiting human TRPV1 activation by 50 nM capsaicin with IC₅₀ of 25 nM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO or 50 mM in ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.5 nM - 50 µM.

A-889425 blocks TRPV1 channels with an IC₅₀ of 335 nM (rat) and 34 nM (human)¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

0.5 nM - 50 µM.

AM 404 activates TRPV1 channels with EC₅₀ = 0.04 µM¹, and serves as a ligand for CB1 cannabinoid receptors².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO, 50 mM in ethanol (dissolves slowly). Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1 nM – 1 µM.

Arvanil is an agonist of TRPV1 channels (EC₅₀ = 0.5 nM), a ligand of CB1 receptors (K_i = 0.25-0.5 μM), and an inhibitor of anandamide accumulation (IC₅₀ = 3.6 µM). In vivo it demonstrates vasodilator, analgesic, and anti-inflammatory properties. Arvanil inhibits human breast cancer cell proliferation and the growth of astrocytoma xenograft tumors in mice^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C.

Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1 nM – 100 nM.

BCTC is a potent and selective antagonist of TRPV1 channels, shown to inhibit capsaicin-, pH- and PKC-induced responses of mouse TRPV1 with IC₅₀ of 1.3, 0.59 and 0.37 nM, respectively.^1,2 BCTC is also a blocker of TRPM8 channels, inhibiting rat TRPM8-mediated menthol and cold-evoked Ca²⁺ response with IC₅₀ of 0.6 µM.³

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

1-10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-10 μM.

Capsaicin is one of the most powerful chemical agonists of the TRPV1 (transient receptor potential vanilloid) channel. It is a small lipophilic molecule derived from hot chili peppers that acts on sensory neurons by opening TRPV1, a principal transduction channel for nociception¹. Capsaicin acts directly on TRPV1², with half-maximal effective concentration of 711.9 nM in Xenopus oocytes³ and 0.29 μM in HEK293 cells⁴.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or six months at -20°C.

0.1-100 µM.

Capsazepine is a selective antagonist of the vanilloid VR1 receptor (TRPV1) with IC₅₀ of 40 nM, and an activator of the ENaC channels.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.1-100 µM.

LASSBio-1135 is a TRPV1 channel and a TNF-α receptor antagonist¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

100 nM - 10 µM.

Nonivamide is a TRPV1 activator¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.5 nM – 50 µM.

OLDA activates TRPV1 channels with an EC₅₀ ~ 0.36 µM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Ethanol and DMSO up to 50 mM. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

0.5 nM - 50 µM.

Olvanil is an opener of TRPV1 channels (EC₅₀ ~ 0.001 µM)¹ and an activator of Cannabinoid receptors².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Ethanol (up to 20.9 mg/ml). Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

5 nM - 5 µM.

Palvanil activates TRPV1 channels at 100 nM in a slower manner than capsaicin¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO 10 mM. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

5 nM - 50 µM.

SB-366791 is a TRPV1 channel antagonist¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

10 nM - 50 µM.

SB-705498 is a potent orally active TRPV1 blocker¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO 100 mM. Centrifuge all product preparations before use (10000 x g 1 min).

Up to four weeks at 4°C or three months at -20°C.