10 nM - 10 μM.

A-803467 is a potent and selective blocker of the TTX-resistant Na_V1.8 channel. A-803467 is a state dependent inhibitor with IC₅₀ of 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states^1,2. A-803467 was used as a pharmacological tool to demonstrate the expression of Na_V1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

200-500 nM.

Inhibits Na_V1.5 and K_V2.1 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

0.5-1 µM.

Jingzhaotoxin XI is a blocker of voltage-gated Na⁺ channel Na_V1.5 with an IC₅₀ value of 124 ± 26 nM and voltage-gated K⁺ channel K_V2.1 with an IC₅₀ value of 390 ± 60 nM¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

200 nM - 2 µM.

Jingzhaotoxin-XII inhibits K_V4.1 and Na_V1.5 voltage-gated channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

10-200 µM.

Ralfinamide mesylate is a Na⁺ channel blocker¹. Its IC₅₀ values for tonic block of half-maximal inactivated tetrodotoxin (TTX)-resistant and TTX-sensitive currents are 10 and 22 μM, respectively¹. Ralfinamide displays analgesic effects in animal models of inflammatory and neuropathic pain².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.