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Home › Products › Ion Channels › Ligand-Gated Ion Channels › Nicotinic Acetylcholine Receptors › Explorer Kits

Certificate of Analysis

Muscle Specific nAChR Antagonist Explorer Kit

A Screening Package of Muscle Specific nAChR Antagonists Economically Priced

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Cat #: EK-207
Size: 10 Vials
Form: Lyophilized

α-Conotoxin EI Cat #: STC-900

Size: 0.1 mg MW: 2094 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
500 nM - 1 µM.
Activity
A selective blocker of α1/β1/γ/δ nAChR.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin GI Cat #: STC-500

Size: 0.5 mg MW: 1438 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10 nM - 1 μM.
Activity
α-Conotoxin GI inhibits α/δ site on mouse muscle-derived BC3H-1 nicotinic acetylcholine receptors (nAChR) expressed on postsynaptic membranes. Other site (α/γ site) on nicotinic receptors from Torpedo californica electric organ is also inhibited by α-Conotoxin GI1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin MI Cat #: STC-370

Size: 0.1 mg MW: 1494 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
2-20 nM.
Activity
α-Conotoxin MI reversibly blocks fetal muscle α1/β1/γ/δ nicotinic ACh receptor1,2,3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

α-Conotoxin SI Cat #: STC-825

Size: 50 µg MW: 1354 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
200-1000 nM.
Activity
α-Conotoxin SI inhibits muscle type α1/β1/δ/γ nicotinic acetylcholine receptors (nAChRs) at 200-1000 nM1 .
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

αA-Conotoxin OIVA Cat #: STC-520

Size: 10 µg MW: 1848 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
100 - 250 nM.
Activity
αA-Conotoxin OIVA blocks α1/β1/g/d (fetal muscle) nAChR1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g for 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

αA-Conotoxin PIVA Cat #: STC-600

Size: 50 µg MW: 2651 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-20 nM
Activity
αA-Conotoxin PIVA reversibly blocks muscle α1/β1/γ/δ nicotinic ACh receptor1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

αC-Conotoxin PrXA Cat #: STC-620

Size: 0.1 mg MW: 3541 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1-20 nM.
Activity
αC-Conotoxin PrXA reversibly blocks both adult and fetal mammalian muscle α1/β1/ε/δ and α1/β1/γ/δ nicotinic ACh receptor1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

Azemiopsin Cat #: STA-100

Size: 0.1 mg MW: 2544 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
0.5-10 µM.
Activity
Azemiopsin blocks the adult form (α1/β1/ε/δ) as well as the fetal form (α1/β1/γ/δ) nAChR1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

(-)-Lobeline hydrochloride Cat #: L-120

Size: 100 mg Source: Synthetic MW: 373.9 Purity: >98%
Effective concentration
0.1-100 µM.
Activity
(-)-Lobeline hydrochloride is a high affinity modulator of nicotinic acetylcholine receptors. It inhibits α7 nAChRs with IC50 of 8.5 µM1.
It also acts on the α4/β2 combination2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Ethanol/water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Waglerin-1 Cat #: STW-001

Size: 1 mg MW: 2520 Da Purity: >99% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
1- 5 µM.
Activity
Waglerin-1 blocks ε subunit of muscle adult nAChR and modulates rodent GABA(A)/GABRA1 receptors1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.
For more information, please refer to individual certificate of analysis for each product.
For research purposes only, not for human use

Related Products

  1. Fasciculin-I (#F-650)
  2. Fasciculin-II (#F-225)
  3. α-Bungarotoxin (#B-100)
  4. Anti-Nicotinic Acetylcholine Receptor α1 (CHRNA1) (extracellular) Antibody (#ANC-001)
  5. Anti-Nicotinic Acetylcholine Receptor β1 (CHRNB1) (extracellular) Antibody (#ANC-011)
  6. nAChR Antibody Explorer Kit (#AK-203)
  7. nAChRα Antibody Explorer Kit (#AK-231)
  8. Muscle-Type nAChR Basic Research Pack (#ESB-900)
  9. Muscle-Type nAChR Premium Research Pack (#ESP-900)
  10. Muscle-Type nAChR Deluxe Research Pack (#ESD-900)

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